IHMT-TRK-284

• Target :

  PDGFR|||c-Kit|||Others|||c-Fms|||Apoptosis|||Trk receptor|||Bcr-Abl

• Related Pathways :

  Others|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis|||Apoptosis

• Bioactivity :

  IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5 nM for TRKA, 0.7 nM for TRKB, and 2.6 nM for TRKC. The compound demonstrates good selectivity within the kinase group and exhibits significant anti-tumor efficacy in vivo.

• Smiles :

  C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(=CC3)C=4SC(NC(CN5CCN(C)CC5)=O)=NC4C)NN2

• Molecular Formula :

  C25H27N7OS

• Molecular Weight :

  473.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2416844-79-4