AMG-8718

CAT: 0931-T62573-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T62573-01Size:25 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1215868-94-2
Target
Beta-Secretase|||Others
Related Pathways
Others|||Neuroscience
Bioactivity
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 ?M) and BACE2 (IC50: 0.005 ?M) . AMG-8718 significantly reduces CSF and A?40 levels in the brain.
Smiles
NC1=N[C@]2(C=3C(OC=4C2=CC(C#CC5(C)COC5)=CN4)=CC=C(C3)C6=C(F)N=CC=C6)CO1
Molecular Formula
C25H19FN4O3
Molecular Weight
442.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C