AMG-8718

• Target:

  Beta-Secretase|||Others

• Related Pathways:

  Others|||Neuroscience

• Bioactivity:

  AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 ?M) and BACE2 (IC50: 0.005 ?M) . AMG-8718 significantly reduces CSF and A?40 levels in the brain.

• Smiles:

  NC1=N[C@]2(C=3C(OC=4C2=CC(C#CC5(C)COC5)=CN4)=CC=C(C3)C6=C(F)N=CC=C6)CO1

• Molecular Formula:

  C25H19FN4O3

• Molecular Weight:

  442.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1215868-94-2