STING Agonist C11

• Target:

  Others|||STING

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 ?M. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1?, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 ?M, respectively), an effect that is dependent on the presence of STING and the IFN-?/? receptor (IFNAR) .

• Smiles:

  C(SC=1OC(=NN1)C2=CC=C(C)C=C2)(C(NC(NC)=O)=O)C3=CC=CC=C3

• Molecular Formula:

  C19H18N4O3S

• Molecular Weight:

  382.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  875863-22-2