STING Agonist 1a

CAT: 0931-T38160-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T38160-01Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

652142-94-4

Target

Others, STING

Related Pathways

Others, Immunology/Inflammation

Bioactivity

STING agonist 1a is an agonist of stimulator of interferon genes (STING) .1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM) . STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

Smiles

ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5

Molecular Formula

C19H11Cl2N5O

Molecular Weight

396.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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