STING Agonist 1a

• Target :

  Others|||STING

• Related Pathways :

  Others|||Immunology/Inflammation

• Bioactivity :

  STING agonist 1a is an agonist of stimulator of interferon genes (STING) .1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 ?M) . STING agonist 1a (12.5-100 ?M) induces expression of IFN-?, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

• Smiles :

  ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5

• Molecular Formula :

  C19H11Cl2N5O

• Molecular Weight :

  396.23

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  652142-94-4