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CAY10412

CAT: 0931-T37684-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T37684-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
390824-17-6
Target
Others|||Cannabinoid Receptor
Related Pathways
GPCR/G Protein|||Others
Bioactivity
Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a facilitated process. Controversy exists as to whether there is a specific AEA transporter, or instead the uptake process is simply driven by hydrolysis of AEA by intracellular fatty acyl amide hydrolase (FAAH) . CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells, with an IC50 of 3 ?M. CAY10412 could be a useful tool for distinguishing the competing transporter theories. The pharmacology of CAY10412 is largely unexplored; it may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations.
Smiles
C(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C=1C=CSC1
Molecular Formula
C25H36O2S
Molecular Weight
400.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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