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CAY10410

CAT: 0931-T35811-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T35811-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
596104-94-8
Target
Others|||PPAR
Related Pathways
Others|||Metabolism|||DNA Damage/DNA Repair
Bioactivity
CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPAR? ligand activity and resistance to metabolism. 15-deoxy-?12,14-PGJ2 has been shown to be a potent ligand for PPAR?. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and ?12-PGJ2 occurs via glutathione addition across the ?, ? unsaturated enone. CAY10410 was designed as an analog of the PPAR?-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 ?M. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 ?M.
Smiles
C(\C=C/CCCCC)=C/1\[C@@H](C/C=C\CCCC(O)=O)CCC1=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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