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CAY10416

CAT: 0931-T36457-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36457-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
443919-96-8
Target
Others|||Lipoxygenase|||COX
Related Pathways
Immunology/Inflammation|||Metabolism|||Others|||Neuroscience
Bioactivity
Dual cyclooxygenase-2 (COX-2) /5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 ?M. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 ?M.
Smiles
O(C)C1(CCOCC1)C2=CC(OCC3=NN(C(=C3)C4=CC=CC=C4)C5=CC=C(S(C)(=O)=O)C=C5)=CC(F)=C2
Molecular Formula
C29H29FN2O5S
Molecular Weight
536.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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