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CAY10487

CAT: 0931-T35985-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T35985-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
778624-05-8
Target
LDLR, Others
Related Pathways
Metabolism, Others
Bioactivity
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits. CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 μM.
Smiles
C(=C/C(N[C@H](C(OC)=O)C)=O)\C1=CC(O)=C(O)C=C1
Molecular Formula
C13H15NO5
Molecular Weight
265.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS5802482CAY10487

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