CAY10721

CAT: 0931-T35821-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T35821-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
848688-62-0
Target
Others|||Sirtuin
Related Pathways
Others|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 ?M) . Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.
Smiles
OC1=CC(NC(=O)CSC2=NC=NC3=C2OC2=C3C=CC=C2)=CC=C1
Molecular Formula
C18H13N3O3S
Molecular Weight
351.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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