NR-160

• Target:

  Others|||HDAC

• Related Pathways:

  DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Others

• Bioactivity:

  NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 ?M) .1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 ?M, respectively) . NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 ?M) . It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

• Smiles:

  N(C(=O)C1=C(C(F)(F)F)C=CC=C1)(CC=2N(CC3=CC=CC=C3)N=NN2)CC4=CC=C(C(NO)=O)C=C4

• Molecular Formula:

  C25H21F3N6O3

• Molecular Weight:

  510.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2484895-50-1