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EGFR-IN-160

CAT: 0931-T207600-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207600-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2172879-84-2
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 μM) and H2O2 (IC50: 8.89 μM) .
Smiles
O=C1N=C(C=C(N1)C=2C=CC(O)=C(OC)C2)C=3OC=CC3
Molecular Formula
C15H12N2O4
Molecular Weight
284.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

6-(furan-2-yl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one
CAS Number2172879-84-2
PubChem CID137301195
IUPAC Name6-(furan-2-yl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one
Molecular FormulaC15H12N2O4
Molecular Weight284.27
XLogP1.6
Topological Polar Surface Area84.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity474
SMILES
COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=CO3)O
InChI
InChI=1S/C15H12N2O4/c1-20-14-7-9(4-5-12(14)18)10-8-11(17-15(19)16-10)13-3-2-6-21-13/h2-8,18H,1H3,(H,16,17,19)
InChIKey
AZXGVYYXWSGGHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(furan-2-yl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one
CAS: 2172879-84-2
CID: 137301195
Formula: C15H12N2O4
MW: 284.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.27
XLogP31.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass284.07970687
Monoisotopic Mass284.07970687
Topological Polar Surface Area84.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity474
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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