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IOR-160

CAT: 0931-T211840-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211840-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2421119-78-8
Target
Casein Kinase, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Stem Cells, Metabolism
Bioactivity
IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.
Smiles
O=C(O)C=1C=CC2=C(N=C(NCCCCCCCC(=O)NO)C=3C=CN=CC23)C1.O=C(O)C(F)(F)F
Molecular Formula
C23H25F3N4O6
Molecular Weight
510.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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