NR-7h

CAT: 0804-HY-153932-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-153932-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NR-7h is a potent and selective p38α and p38β degrader with DC50 values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively[1].

CAS Number

2550399-06-7

UNSPSC

12352005

Target

P38 MAPK; PROTACs

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nr-7h.html

Purity

96.9

Solubility

10 mM in DMSO

Smiles

O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5

Molecular Formula

C48H50BrF2N9O8

Molecular Weight

998.87

References & Citations

[1]Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. Eur J Med Chem. 2020 Sep 1;201:112451.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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