NR-7h

• Description :

  NR-7h is a potent and selective p38α and p38β degrader with DC50 values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively[1].

• UNSPSC :

  12352005

• Target :

  P38 MAPK; PROTACs

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nr-7h.html

• Purity :

  96.9

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5

• Molecular Formula :

  C48H50BrF2N9O8

• Molecular Weight :

  998.87

• References & Citations :

  [1]Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. Eur J Med Chem. 2020 Sep 1;201:112451.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2550399-06-7]