NR-7h

• Description:

  NR-7h is a potent and selective p38α and p38β degrader with DC50 values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively[1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nr-7h.html

• Purity:

  96.9

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5

• Molecular Formula:

  C48H50BrF2N9O8

• Molecular Weight:

  998.87

• References & Citations:

  [1]Donoghue C, et al. Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. Eur J Med Chem. 2020 Sep 1;201:112451.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2550399-06-7]