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CAY10487

CAT: 0931-T35985-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T35985-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
778624-05-8
Target
LDLR, Others
Related Pathways
Metabolism, Others
Bioactivity
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits. CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 μM.
Smiles
C(=C/C(N[C@H](C(OC)=O)C)=O)\C1=CC(O)=C(O)C=C1
Molecular Formula
C13H15NO5
Molecular Weight
265.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3,4-Dihydrocinnamic acid (L-alanine methyl ester) amide
CAS Number778624-05-8
PubChem CID23659588
IUPAC Namemethyl (2S)-2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propanoate
Molecular FormulaC13H15NO5
Molecular Weight265.26
XLogP1.2
Topological Polar Surface Area95.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count19
Formal Charge0
Complexity355
SMILES
C[C@@H](C(=O)OC)NC(=O)/C=C/C1=CC(=C(C=C1)O)O
InChI
InChI=1S/C13H15NO5/c1-8(13(18)19-2)14-12(17)6-4-9-3-5-10(15)11(16)7-9/h3-8,15-16H,1-2H3,(H,14,17)/b6-4+/t8-/m0/s1
InChIKey
WFBBISJLIGYSGF-JQTRYQTASA-N
Chemical Structure
2D Structure
2D structure of 3,4-Dihydrocinnamic acid (L-alanine methyl ester) amide
CAS: 778624-05-8
CID: 23659588
Formula: C13H15NO5
MW: 265.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.26
XLogP31.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass265.09502258
Monoisotopic Mass265.09502258
Topological Polar Surface Area95.9 Ų
Heavy Atom Count19
Formal Charge0
Complexity355
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS5802482CAY10487

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