CAY10443

CAT: 0931-T36190-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T36190-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
582314-48-5
Target
Apoptosis|||Caspase|||PARP|||Others|||Mitochondrial Metabolism|||DNA/RNA Synthesis
Related Pathways
Others|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Proteases/Proteasome|||Apoptosis|||Metabolism|||DNA Damage/DNA Repair
Bioactivity
Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 ?M. These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.
Smiles
O(C(NCC1=CC(Cl)=C(Cl)C=C1)=O)[C@@H]2C=3C(CC2)=CC=CC3
Molecular Formula
C17H15Cl2NO2
Molecular Weight
336.21
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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