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CAY10787

CAT: 0931-T37201-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T37201-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
567-72-6
Target
GABA Receptor|||Others
Related Pathways
Neuroscience|||Others|||Membrane transporter/Ion channel
Bioactivity
CAY10787 is an oxysterol and a negative allosteric modulator of GABAAreceptors.1,2It reduces GABA-induced currents in HEK cells expressing ?1?1?2or ?4?3?2subunit-containing GABAAreceptors (IC50s = 1.5 and 1 ?M, respectively) .2CAY10787 (500 nM) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons.
Smiles
[H][C@@]1(CC[C@@]2([H])[C@]3([H])C(=O)C=C4C=CCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C|c:12,t:10|
Molecular Formula
C27H42O
Molecular Weight
382.632
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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