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Afeletecan free base

CAT: 0931-T23654Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T23654Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
215604-75-4
Target
Others
Related Pathways
Others
Bioactivity
Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double-strand DNA breakage, and triggering of apoptosis.
Smiles
O(C([C@@H](NC([C@H](CC1=CN=CN1)NC(NC2=CC=C(O[C@@H]3[C@@H](O)[C@H](OC)[C@H](O)[C@H](C)O3)C=C2)=S)=O)C(C)C)=O)[C@@]4(CC)C5=C(C(=O)N6C(=C5)C=7C(C6)=CC=8C(N7)=CC=CC8)COC4=O
Molecular Formula
C45H49N7O11S
Molecular Weight
895.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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