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Afeletecan HCl

CAT: 0931-T69862-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69862-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
215604-74-3
Target
Others
Related Pathways
Others
Bioactivity
Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood.
Smiles
Cl.CC[C@@]1(OC(=O)[C@@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=S)Nc2ccc(O[C@H]3O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]3O)cc2)C(C)C)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
Molecular Formula
C45H50ClN7O11S
Molecular Weight
932.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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