(±) -AMG 487

• Target :

  CXCR|||Others

• Related Pathways :

  Autophagy|||Immunology/Inflammation|||GPCR/G Protein|||Others

• Bioactivity :

  AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively) .

• Smiles :

  CCOC1=CC=C(N2C(C(N(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC4=CN=CC=C4)C)=NC5=C(C2=O)C=CC=N5)C=C1

• Molecular Formula :

  C32H28F3N5O4

• Molecular Weight :

  603.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C