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Lenalidomide hydrochloride

CAT: 0931-T21763-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T21763-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1243329-97-6
Target
Molecular Glues, Ligand for E3 Ligase, Others
Related Pathways
Others, PROTAC
Bioactivity
Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase. Specifically, Lenalidomide hydrochloride inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and promotes IL-2 release from T cells [1] [2].
Smiles
Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(N)C3C2)CC1
Molecular Formula
C13H14ClN3O3
Molecular Weight
295.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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