Lenalidomide hydrochloride

• CAS Number :

  1243329-97-6

• Target :

  Molecular Glues|||Ligand for E3 Ligase|||Others

• Related Pathways :

  Others|||PROTAC

• Bioactivity :

  Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase. Specifically, Lenalidomide hydrochloride inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and promotes IL-2 release from T cells [1] [2].

• Smiles :

  Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(N)C3C2)CC1

• Molecular Formula :

  C13H14ClN3O3

• Molecular Weight :

  295.72

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C