Lenalidomide hydrochloride

• Target:

  Molecular Glues|||Ligand for E3 Ligase|||Others

• Related Pathways:

  Others|||PROTAC

• Bioactivity:

  Lenalidomide hydrochloride (CC-5013 hydrochloride), a Thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. As a ligand for the ubiquitin E3 ligase cereblon (CRBN), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase. Specifically, Lenalidomide hydrochloride inhibits the growth of mature B-cell lymphomas, including multiple myeloma, and promotes IL-2 release from T cells [1] [2].

• Smiles:

  Cl.O=C1NC (=O) C (N2C (=O) C=3C=CC=C (N) C3C2) CC1

• Molecular Formula:

  C13H14ClN3O3

• Molecular Weight:

  295.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1243329-97-6