Lenalidomide-5-aminomethyl (hydrochloride)

• UNSPSC Description:

  Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]

• Target Antigen:

  Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lenalidomide-5-aminomethyl-hydrochloride.html

• Purity:

  99.73

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  [H]Cl.O=C(C(N(CC1=C2C=CC(CN)=C1)C2=O)CC3)NC3=O

• Molecular Weight:

  309.753

• References & Citations:

  [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1158264-69-7