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Lenalidomide-C4-NH2 hydrochloride

CAT: 0931-T17878Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T17878Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC, Others
Bioactivity
Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].
Smiles
O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
Molecular Formula
C17H22ClN3O3
Molecular Weight
351.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-115446A-01Lenalidomide-C4-NH2 (hydrochloride)
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