Lenalidomide

CAT: 0931-T1642-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T1642-01Size:50 mg

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CAS Number

191732-72-6

Target

Ligand for E3 Ligase, Apoptosis, IKZF, Molecular Glues, TNF

Related Pathways

Apoptosis, Immunology/Inflammation, PROTAC

Purity

0.9997

Bioactivity

Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.

Smiles

NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1

Molecular Formula

C13H13N3O3

Molecular Weight

259.26

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Lenalidomide

Lenalidomide is a dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator. It is a member of isoindoles, an aromatic amine, a dicarboximide and a member of piperidones.

CAS Number	191732-72-6
PubChem CID	216326
IUPAC Name	3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Molecular Formula	C13H13N3O3
Molecular Weight	259.26
XLogP	-0.5
Topological Polar Surface Area	92.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	19
Formal Charge	0
Complexity	437

SMILES

C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

InChI

InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChIKey

GOTYRUGSSMKFNF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 191732-72-6

CID: 216326

Formula: C13H13N3O3

MW: 259.26

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	259.26
XLogP3	-0.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	259.09569129
Monoisotopic Mass	259.09569129
Topological Polar Surface Area	92.5 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	437
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
FL24864-01	Lenalidomide

Lenalidomide

Chemical Information

Alternative Products

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