SR-1114

• Product Name Alternative:

  CA-074Me

• UNSPSC Description:

  SR-1114 is a first-in-class PROTAC ENL degrader. SR-1114 elicits rapid, CRBN-dependent degradation of ENL with DC50s of 150 nM, 311 nM, and 1.65 μM in MV4;11 , MOLM-13, and OCI/AML-2 cells, respectively[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sr-1114.html

• Purity:

  99.04

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCOCCOCCNS(=O)(NC1=CC=CC(C2=CN3C=C(C=CC3=N2)C(NC4CCC4)=O)=C1)=O)COC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O

• Molecular Weight:

  830.86

• References & Citations:

  [1]Leopold Garnar-Wortzel, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2769141-82-2