SR-1114

• Description:

  SR-1114 is a PROTAC degrader targeting ENL. SR-1114 degrades ENL in a CRBN-dependent manner and selectively downregulates ENL target genes. SR-1114 can promote the differentiation of acute myeloid leukemia cells. SR-1114 can be used in tumor research. (Pink: ENL ligand (HY-145409) ; Black: Linker; Blue: E3 Ligand (HY-14658) ) [1].

• Product Name Alternative:

  CA-074Me

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sr-1114.html

• Purity:

  99.04

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCOCCOCCNS(=O)(NC1=CC=CC(C2=CN3C=C(C=CC3=N2)C(NC4CCC4)=O)=C1)=O)COC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O

• Molecular Formula:

  C39H42N8O11S

• Molecular Weight:

  830.86

• References & Citations:

  [1]Leopold Garnar-Wortzel, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7 (5) :815-830.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [2769141-82-2]