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OARV-771

CAT: 0804-HY-145264-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145264-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].
CAS Number
2683008-37-7
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oarv-771.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(OCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C7=NN=C(C)N27
Molecular Formula
C49H59ClN8O8S2
Molecular Weight
987.62
References & Citations
[1]Klein VG, et al. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem. 2021;64 (24) :18082-18101.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD3; BRD4; von Hippel-Lindau (VHL)

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T74391-01OARV-771
A24409-100OARV-771 100mg
A24409-50OARV-771 50mg
A24409-5OARV-771 5mg
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BA4656-50ARV-771
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7256/5ARV 771

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