ARV-771 (Standard)

• Description:

  ARV-771 (Standard) is the analytical standard of ARV-771 (HY-100972) . This product is intended for research and analytical applications. ARV-771 is a potent BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1), and BRD4 (2), respectively[1].

• Target:

  Epigenetic Reader Domain; PROTACs; Reference Standards

• Related Pathways:

  Epigenetics; Others; PROTAC

• Field of Research:

  Cancer

• Smiles:

  CC(C(C(C1=CC=C(Cl)C=C1)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C2)[C@@H]2C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C

• Molecular Formula:

  C49H60ClN9O7S2

• Molecular Weight:

  986.64

• References & Citations:

  [1]Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113 (26) :7124-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [1949837-12-0]