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OART

CAT: 0804-HY-177483Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177483Size:1 Each
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Description
OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research[1].
Product Name Alternative
Oxaliplatin-artesunate
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Ferroptosis; Glutathione Peroxidase; Mitochondrial Metabolism; MMP; Transferrin Receptor
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
[OH-][Pt+4]12([O-]C(C([O-]2)=O)=O)(OC(CCC(O[C@@H]([C@@H]([C@@]3(CC[C@H]([C@@]4(CC5)[H])C)[H])C)O[C@](O[C@]65C)([C@]34OO6)[H])=O)=O)[NH2][C@@]7([H])[C@](CCCC7)([H])[NH2]1
Molecular Formula
C27H42N2O13Pt+
Molecular Weight
797.71
References & Citations
[1]Fan R, et al. A platinum (IV) -artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy. MedComm (2020) . 2024 May 20;5 (6) :e570.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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