BAY-771

• Description:

  BAY-771, a structurally close pyrimidinedione, is a chemical probe with good lead-like properties and high permeability in Caco-2 cells (no hint of efflux) . BAY-771 shows very weak inhibitory activity in the BCAT1 biochemical assay and no activity in BCAT2. BAY-771 can be used as a negative control of HY-148242 BAY-069. BAY-771 can be used for the research of tumor metabolism[1].

• UNSPSC:

  12352005

• Target:

  Fluorescent Dye

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bay-771.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C(F)(F)F)=CC(N1C2=CC(OC3=C(C)C=CC=C3)=CC4=C2C=CC=C4)=O

• Molecular Formula:

  C22H15F3N2O3

• Molecular Weight:

  412.36

• References & Citations:

  [1]Günther J, et al. BAY-069, a Novel (Trifluoromethyl) pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J Med Chem. 2022 Nov 10;65 (21) :14366-14390.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2771756-82-0]