AR-A014418

• Description :

  AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM) [1].

• Product Name Alternative :

  AR 0133418; GSK 3β inhibitor VIII; AR 014418

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H318, H335

• Target :

  GSK-3

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/AR-A014418.html

• Concentration :

  10mM

• Purity :

  99.21

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2

• Molecular Formula :

  C12H12N4O4S

• Molecular Weight :

  308.31

• Precautions :

  H302, H315, H318, H335

• References & Citations :

  [1]Bhat R, Xue Y, Berg S, Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003 Nov 14;278 (46) :45937-45.|[2]Carter YM, et al. Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther. 2014 May;15 (5) :510-5.|[3]Koh SH, et al. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Exp Neurol. 2007 Jun;205 (2) :336-46|[4]Martins DF, et al. The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice. J Pain. 2011 Mar;12 (3) :315-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GSK-3β

• CAS Number :

  [487021-52-3]