AR A014418

• Background:

  AR A014418 is a highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. GSK-3 is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. AR A014418 is cell permeable.

• Description:

  GSK-3 kinase inhibitor

• Product Name Alternative:

  N- (4-Methoxybenzyl) -N′- (5-nitro-1,3-thiazol-2-yl) urea

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥95% (HPLC)

• Weight:

  0.025

• Format:

  White to off-white solid

• Solubility:

  Soluble in DMSO, methanol, 100% ethanol or ethyl acetate

• Molecular Formula:

  C12H12N4O4S

• Molecular Weight:

  308.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Bhat R.V., & Budd S.L. (2002) Neuro-Signals. 11(5): 251–261. 2. Gould T.D., Einat H., Bhat R., & Manji H.K. (2004) Int. J. Neuropsychopharmacology (CINP). 7(4): 387–390.

• CAS Number:

  487021-52-3