JTK-853

JTK-853

• CAS Number: 954389-09-4
• UNSPSC Description: JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0.38 and 0.035 μM in genotype 1a H77 and 1b Con1 strains, respectively.
• Target Antigen: HCV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/JTK-853.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H]1N(S(=O)(C2=CC=C(C(F)(F)F)C=C2)=O)CCN(C3=NC4=NC(C5CC5)=NC=C4S3)C1)NCC6=CC=C(OC(F)(F)F)C(F)=C6
• Molecular Weight: 704.64
• References & Citations: [1]Ando I, et al. JTK-853, a novel non-nucleoside hepatitis C virus polymerase inhibitor, demonstrates a high genetic barrier to resistance in vitro. Intervirology. 2013;56(5):302-9.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 1