UNC-2170

• Description :

  UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM) . UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].

• CAS Number :

  [1648707-58-7]

• Product Name Alternative :

  PQQ (disodium salt); Methoxatin (disodium salt), PQQ; Methoxatin

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/unc-2170.html

• Purity :

  98.84

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1

• Molecular Formula :

  C14H21BrN2O

• Molecular Weight :

  313.23

• References & Citations :

  [1]Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10 (4) :1072-1081.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported