UNC-2170

• Description:

  UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM) . UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].

• Product Name Alternative:

  PQQ (disodium salt); Methoxatin (disodium salt), PQQ; Methoxatin

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/unc-2170.html

• Purity:

  98.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1

• Molecular Formula:

  C14H21BrN2O

• Molecular Weight:

  313.23

• References & Citations:

  [1]Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10 (4) :1072-1081.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1648707-58-7]