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UNC-2170

CAT: 0804-HY-115531-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-115531-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM) . UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].
CAS Number
[1648707-58-7]
Product Name Alternative
PQQ (disodium salt); Methoxatin (disodium salt)
,
PQQ; Methoxatin
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc-2170.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)
Smiles
O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1
Molecular Formula
C14H21BrN2O
Molecular Weight
313.23
References & Citations
[1]Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10 (4) :1072-1081.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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