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KW-2170 (hydrochloride)

CAT: 0804-HY-19211Size: 1 EachDry Ice: NoHazardous: No
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Description
KW-2170 hydrochloride is an alkylating agent and topoisomerase II inhibitor. KW-2170 hydrochloride stabilizes the topoisomerase II-DNA complex, causing DNA double-strand breaks, thereby preventing DNA replication and transcription, and ultimately leading to the death of tumor cells. KW-2170 hydrochloride exhibits potent and broad-spectrum anti-tumor activity in various mouse and human tumor models. KW-2170 hydrochloride can be used in the research of solid tumors[1][2].
CAS Number
207862-44-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1C2=C(C(O)=CC=C2O)N(N=C3CNCCO)C4=C3C=CC(NCCCN)=C14.Cl.Cl
Molecular Formula
C20H25Cl2N5O4
Molecular Weight
470.35
References & Citations
[1]Ashizawa T, et al. Antitumor activity of KW-2170, a novel pyrazoloacridone derivative. Anticancer Drugs. 1998 Mar;9 (3) :263-71. |[2]Verschraegen CF. KW-2170 (Kyowa Hakko Kogyo) . IDrugs. 2002 Oct;5 (10) :1000-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo II

Chemical Information

6H-Pyrazolo(4,5,1-de)acridin-6-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(((2-hydroxyethyl)amino)methyl)-, dihydrochloride
CAS Number207862-44-0
PubChem CID3075774
IUPAC Name10-(3-aminopropylamino)-3,8-dihydroxy-14-[(2-hydroxyethylamino)methyl]-1,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-2,4,7,9,11,13(16),14-heptaen-6-one;dihydrochloride
Molecular FormulaC20H25Cl2N5O4
Molecular Weight470.3
Topological Polar Surface Area146
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity749
SMILES
C1=CC(=C2C3=C1C(=NN3C4=C(C=CC(=O)C4=C2O)O)CNCCO)NCCCN.Cl.Cl
InChI
InChI=1S/C20H23N5O4.2ClH/c21-6-1-7-23-12-3-2-11-13(10-22-8-9-26)24-25-18(11)16(12)20(29)17-14(27)4-5-15(28)19(17)25;;/h2-5,22-23,26,28-29H,1,6-10,21H2;2*1H
InChIKey
FSJDQJHSJAGEJV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6H-Pyrazolo(4,5,1-de)acridin-6-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(((2-hydroxyethyl)amino)methyl)-, dihydrochloride
CAS: 207862-44-0
CID: 3075774
Formula: C20H25Cl2N5O4
MW: 470.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.3
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass469.1283597
Monoisotopic Mass469.1283597
Topological Polar Surface Area146 Ų
Heavy Atom Count31
Formal Charge0
Complexity749
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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