UNC-CA359

• Description :

  UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research[1]. UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/unc-ca359.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC(C(C#C)=C1)=CC=C1NC2=C3C(C=C(C(OC)=C3)OC)=NC=N2

• Molecular Formula :

  C18H14ClN3O2

• Molecular Weight :

  339.78

• References & Citations :

  [1]Bieberich AA, et al. Optimization of the 4-anilinoquin (az) oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27. 12 (1) :12820.|[2]Asquith CRM, et al. Design and Analysis of the 4-Anilinoquin (az) oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem. 2020 Jan 7. 15 (1) :26-49.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2676156-05-9]