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UNC-CA359

CAT: 0804-HY-150782Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150782Size:1 Each
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Description
UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research[1]. UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2676156-05-9
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc-ca359.html
Solubility
10 mM in DMSO
Smiles
ClC(C(C#C)=C1)=CC=C1NC2=C3C(C=C(C(OC)=C3)OC)=NC=N2
Molecular Formula
C18H14ClN3O2
Molecular Weight
339.78
References & Citations
[1]Bieberich AA, et al. Optimization of the 4-anilinoquin (az) oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27. 12 (1) :12820.|[2]Asquith CRM, et al. Design and Analysis of the 4-Anilinoquin (az) oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem. 2020 Jan 7. 15 (1) :26-49.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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