UNC 669

• Description :

  UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor[1].

• CAS Number :

  [1314241-44-5]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/unc-669.html

• Purity :

  99.74

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC(Br)=CN=C1)N2CCC(N3CCCC3)CC2

• Molecular Formula :

  C15H20BrN3O

• Molecular Weight :

  338.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]James LI, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56 (18) :7358-71.|[2]Trojer P, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell. 2007;129 (5) :915-928.|[3]Baughman BM, et al. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer [retracted in: ACS Chem Biol. 2018 Jan 19;13 (1) :281]. ACS Chem Biol. 2016;11 (3) :722-728.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported