UNC 0631

• Description:

  UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC50 of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 25 nM[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/UNC-0631.html

• Purity:

  99.27

• Solubility:

  DMF : 150 mg/mL (ultrasonic) |DMSO : 16.67 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=CC2=C(NC3CCN(CC4CCCCC4)CC3)N=C(N5CCN(C(C)C)CCC5)N=C2C=C1OCCCN6CCCCC6

• Molecular Formula:

  C37H61N7O2

• Molecular Weight:

  635.93

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54 (17) :6139-50.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EHMT2/G9a/KMT1C

• CAS Number:

  1320288-19-4