UNC-CA2-103

• Description:

  UNC-CA2-103 (compound 128) is a potent inhibitor of Tousled like kinase 2 (TLK2), with the IC50 of 18 nM[1].

• UNSPSC:

  12352005

• Target:

  Ser/Thr Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/unc-ca2-103.html

• Concentration:

  10mM

• Purity:

  99.26

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC2=C(NC(/C2=C\C3=C(C)N=CN3)=O)C=C1)C4=CC=CC=C4

• Molecular Formula:

  C20H16N4O2

• Molecular Weight:

  344.37

• References & Citations:

  [1]Jia-Wei Zhang, et al. Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships. Oncol Lett. 2018 Feb;15 (2) :1811-1816.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported