UNC-CA2-103

• Description :

  UNC-CA2-103 (compound 128) is a potent inhibitor of Tousled like kinase 2 (TLK2), with the IC50 of 18 nM[1].

• UNSPSC :

  12352005

• Target :

  Ser/Thr Kinase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/unc-ca2-103.html

• Concentration :

  10mM

• Purity :

  99.26

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC2=C(NC(/C2=C\C3=C(C)N=CN3)=O)C=C1)C4=CC=CC=C4

• Molecular Formula :

  C20H16N4O2

• Molecular Weight :

  344.37

• References & Citations :

  [1]Jia-Wei Zhang, et al. Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships. Oncol Lett. 2018 Feb;15 (2) :1811-1816.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported