Thalidomide-Piperazine 5-fluoride (hydrochloride)

Thalidomide-Piperazine 5-fluoride (hydrochloride)

• CAS Number: 2222114-23-8
• UNSPSC Description: Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-piperazine-5-fluoride-hydrochloride.html
• Purity: 98.91
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(C(CC1)N2C(C3=CC(F)=C(N4CCNCC4)C=C3C2=O)=O)=O.Cl
• Molecular Weight: 396.80
• References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature, keep dry and cool
• Clinical Information: No Development Reported