CK-869

• Description :

  CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H361, H372, H410

• Target :

  Arp2/3 Complex

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CK-869.html

• Purity :

  99.94

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C2=CC=C(OC)C=C2OC)C(C3=CC=CC(Br)=C3)SC1

• Molecular Formula :

  C17H16BrNO3S

• Molecular Weight :

  394.28

• Precautions :

  H302, H361, H372, H410

• References & Citations :

  [1]Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20 (5) :701-12.|[2]Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496 (3) :834-839.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [388592-44-7]