CK-666

• Description:

  CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM) . CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Arp2/3 Complex; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cytoskeleton

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/ck-666.html

• Purity:

  99.95

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F

• Molecular Formula:

  C18H17FN2O

• Molecular Weight:

  296.34

• Precautions:

  H302

• References & Citations:

  +

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  [442633-00-3]