CK-666

• UNSPSC Description:

  CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2].

• Target Antigen:

  Arp2/3 Complex; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cytoskeleton

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/ck-666.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F

• Molecular Weight:

  296.34

• References & Citations:

  [1]Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.|[2]Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4⁺ T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  442633-00-3