CK-548

• Description :

  CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2].

• Product Name Alternative :

  CK-0993548

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H400

• Target :

  Arp2/3 Complex; HIV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cytoskeleton

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ck-548.html

• Purity :

  90

• Smiles :

  O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O

• Molecular Formula :

  C15H11BrClNO2S

• Molecular Weight :

  384.68

• Precautions :

  H302, H400

• References & Citations :

  [1]B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.|[2]Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289 (10) :6949-6959.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [388604-55-5]