CK-548

• Description:

  CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2].

• Product Name Alternative:

  CK-0993548

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H400

• Target:

  Arp2/3 Complex; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cytoskeleton

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ck-548.html

• Purity:

  90

• Smiles:

  O=C1N (C (SC1) C2=CC=CC (Br) =C2) C3=CC (Cl) =CC=C3O

• Molecular Formula:

  C15H11BrClNO2S

• Molecular Weight:

  384.68

• Precautions:

  H302, H400

• References & Citations:

  [1]B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.|[2]Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289 (10) :6949-6959.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  388604-55-5