CK-548

• Product Name Alternative:

  CK-0993548

• UNSPSC Description:

  CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2].

• Target Antigen:

  Arp2/3 Complex; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cytoskeleton

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ck-548.html

• Smiles:

  O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O

• Molecular Weight:

  384.68

• References & Citations:

  [1]B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.|[2]Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289(10):6949-6959.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  388604-55-5