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Mitotane-13C12

CAT: 0804-HY-13690S3Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13690S3Size:1 Each
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Description
Mitotane-13C12 (2,4′-DDD-13C12) is 13C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[1][2][3][4][1][2][3][4][5].
CAS Number
[2483736-36-1]
Product Name Alternative
2,4′-DDD-13C12; o, p'-DDD-13C12
UNSPSC
12352101
Target
Apoptosis; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mitotane-13c12.html
Smiles
ClC(Cl)C([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)Cl)[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)Cl
Molecular Formula
C2 13C12H10Cl4
Molecular Weight
331.95
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Takeshita A, Igarashi-Migitaka J, Koibuchi N, Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor. J Endocrinol. 2013 Feb 15;216 (3) :297-305.|[3]Doghman M, et al. Lack of long-lasting effects of mitotane adjuvant therapy in a mouse xenograft model of adrenocortical carcinoma. Mol Cell Endocrinol. 2013 Dec 5;381 (1-2) :66-9.|[4]Zatelli MC, et al. Therapeutic concentrations of mitotane (o, p'-DDD) inhibit thyrotroph cell viability and TSH expression and secretion in a mouse cell line model. Endocrinology. 2010 Jun;151 (6) :2453-61.|[5]Warde KM, et al. Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma. Endocrinology. 2022 Sep 1;163 (9) :bqac102.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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