Phenylbutyrate Na, HDAC inhibitor
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Catalog numberSIH-255-100MG
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PricePlease ask
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Size100 mg
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Stock availabilitIn StockIn Stock
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CAS number1716-12-7
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DescriptionHDAC inhibitor
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Molecular weight186,18 g/mol
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Primary research fieldsCancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors
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Other nameSodium 4-phenylbutanoate, 4-PB
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Product categorySmall Molecules
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Product typeInducer
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Chemical formulaC10H11NaO2
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble to 1100 mM in water and 100 mM in DMSO
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number5258
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Scientific contextSodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
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Bibliography1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54. 2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.
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Release date8-Apr-2011
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Phenylbutyrate Na (SIH-255), a Histone deacetylase inhibitor. CAS #: 1716-12-7. Molecular Formula: C10H11NaO2. Molecular Weight: 186.18 g/mol. Chemical structure of Phenylbutyrate Na, a Histone deacetylase inhibitor (SIH-255). CAS # 1716-12-7. Molecular Formula: C10H11NaO2.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.1
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolHDAC4, HDAC9
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Short namePhenylbutyrate Na, HDAC inhibitor
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Alternative namePhenylbutyrate Na, HDAC suppressor
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Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID