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Stock availabilitIn Stock
In Stock
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CAS number
209783-80-2
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Description
HDAC inhibitor
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Molecular weight
376,41 g/mol
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Primary research fields
Cell Signaling, Epigenetics, Cancer
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Other name
3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C21H20N4O3
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Origin
Synthetic
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Purity pourcentage
>98.5
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Soluble in
Soluble in DMSO or methanol.
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Physical appearance
Off white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: D1B Toxic Material Causing Immediate and SeriousToxic Effects, Toxic by ingestion, D2A Very Toxic Material Causing Other Toxic Effects, Teratogen, D2B Toxic Material Causing Other Toxic Effects, Reproductive hazard, Moderate skin irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H360 May damage fertility or the unborn child. Precautionary statements: P201 Obtain special instructions before use. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention.
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PubChem number
4261
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Scientific context
MS 275, also referred to as Entinostat, is a benzamide histone deacetylase inhibitor. It preferentially inhibits HDAC1 and HDAC3. It is currently undergoing several clinical trials for the treatment of Hodgkin's lymphoma, advanced breast cancer, and for metastatic lung cancer.
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Bibliography
1. Camphausen K., Burgan W., Cerra M., Oswald K.A., Trepel J.B., Lee M.J., et al. (2004) Cancer Res. 316-21.
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Release date
21-May-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of MS 275 (SIH-416), a HDAC inhibitor. CAS #: 209783-80-2. Molecular Formula: C21H20N4O3. Molecular Weight: 376.41 g/mol. Chemical structure of MS 275, a HDAC inhibitor (SIH-416). CAS # 209783-80-2. Molecular Formula: C21H20N4O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
