Apicidin, HDAC inhibitor
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Catalog numberSIH-346-1MG
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Price:
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Size1 mg
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Stock availabilitIn StockIn Stock
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CAS number183506-66-3
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DescriptionHDAC inhibitor
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Molecular weight623,8 g/mol
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Primary research fieldsCell Signaling, Epigenetics, Cancer
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Other name(3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone; Cyclo(N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC34H49N5O6
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OriginSynthetic
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Purity pourcentage>98% (HPLC); NMR (conforms)
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Soluble inSoluble in 10 mg/ml DMSO or 100% Ethanol
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Physical appearanceWhite Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Toxic. May be harmful or fatal if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H300+H310 – Fatal if swallowed or in contact with skin. H330 – Fatal if inhaled Precautionary Statements: P260 – Do not breathe dust/fumes/gas/mist/vapours/spray P264- Wash hands thoroughly after handling P280 – Wear protective gloves/ Protective clothing P284 – Wear respiratory protection P302 + P350 – If on skin: Gently wash with plenty of soap and water. P310 – Immediately call a poison center or doctor/ physician
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PubChem number6918328
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Scientific contextCyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
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Bibliography1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143. 2. Han J.W., et al. (2000) Cancer Res. 60: 6068. 3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.
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Release date1-Aug-2012
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Apicidin (SIH-346), a HDAC inhibitor. CAS #: 183506-66-3. Molecular Formula: C34H49N5O6 . Molecular Weight: 623.8 g/mol. Chemical structure of Apicidin, a HDAC inhibitor (SIH-346). CAS # 183506-66-3. Molecular Formula: C34H49N5O6 .
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.001
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolHDAC4, HDAC9
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Short nameApicidin, HDAC inhibitor
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Alternative nameApicidin, HDAC suppressor
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Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID