Sodium Valproate, HDAC inhibitor
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Catalog number
SIH-357-5G
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Price
Please ask
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Size
5 g
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Stock availabilitIn Stock
In Stock
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CAS number
1069-66-5
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Description
HDAC inhibitor
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Molecular weight
166,2 g/mol
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Primary research fields
Cell Signaling, Epigenetics, Cancer
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Other name
2-Propylpentanoic acid Na
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C8H15NaO2
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Origin
Synthetic
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Purity pourcentage
>98% (TLC), NMR conforms
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Soluble in
Soluble in 50 mg/ml Water
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
16760703
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Scientific context
Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits Aβ production and neuritic plaque formation in Alzheimer’s mouse models. Clinically useful anticonvulsant.
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Bibliography
1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734. 2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892. 3. Qing H., et al. (2008) J. Exp. Med. 205: 2781.
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Release date
1-Aug-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Sodium Valproate (SIH-357), a HDAC inhibitor. CAS #: 1069-66-5. Molecular Formula: C8H15NaO2 . Molecular Weight: 166.2 g/mol. Chemical structure of Sodium Valproate, a HDAC inhibitor (SIH-357). CAS # 1069-66-5. Molecular Formula: C8H15NaO2 .
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
5
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
HDAC4, HDAC9
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Short name
Sodium Valproate, HDAC inhibitor
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Alternative name
Sodium Valproate, HDAC suppressor
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Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year
2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID
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