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Stock availabilitIn Stock
In Stock
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CAS number
58880-19-6
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Description
HDAC inhibitor
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Molecular weight
302,37 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors
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Other name
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C17H22N2O3
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 10 mM in ethanol and to 50 mM in DMSO
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Physical appearance
Beige Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R68 - Possible risk of irreversible effects Hazard Phrases: H302-H312-H315-H317-H319-H332-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
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PubChem number
444732
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Scientific context
Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).
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Bibliography
1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643. 2. Yoshida, et al. (1990) J Biol Chem. 165: 17174. 3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Trichostatin A (SIH-254), a Histone deacetylase inhibitor. CAS #: 58880-19-6. Molecular Formula: C17H22N2O3. Molecular Weight: 302.37 g/mol. Chemical structure of Trichostatin A, a Histone deacetylase inhibitor (SIH-254). CAS # 58880-19-6. Molecular Formula: C17H22N2O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
