HPA, HDAC inhibitor

• Catalog number
  SIH-356-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  96017-59-3
• Description
  HDAC inhibitor
• Molecular weight
  182,3 g/mol
• Primary research fields
  Cell Signaling, Epigenetics, Cancer
• Other name
  2-(2-propynyl)octanoic acid, HPA
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C11H11O2
• Origin
  Synthetic
• Purity pourcentage
  >97% (TLC), NMR conforms
• Soluble in
  Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
• Physical appearance
  Colorless Oil
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
• PubChem number
  175664
• Scientific context
  Histone deacetylase (HDAC) inhibitor, IC50=13 µM Histone deacetylase (HDAC) inhibitor, IC50=13 µM
• Bibliography
  1. Eikel D., et al. (2006) Chem. Res. Toxicol. 19: 272. 2. Leng Y., et al. (2010) Neurosci. Lett. 476: 127.
• Release date
  1-Aug-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Hexyl-4-pentynoic Acid (SIH-356), a HDAC inhibitor. CAS #: 96017-59-3. Molecular Formula: C11H11O2. Molecular Weight: 182.3 g/mol. Chemical structure of Hexyl-4-pentynoic Acid, a HDAC inhibitor (SIH-356). CAS # 96017-59-3. Molecular Formula: C11H11O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  HPA   HDAC   inhibitor  
• Gene symbol
  HDAC4, HPSE, HDAC9
• Short name
  HPA, HDAC inhibitor
• Alternative name
  HPA, HDAC suppressor

Gene info

• Identity
  HGNC:14063
• Gene
  HDAC4
• Long gene name
  histone deacetylase 4
• Synonyms gene
  • BDMR
• Synonyms gene name
  • brachydactyly-mental retardation syndrome
• Synonyms
  • KIAA0288
  • HDAC-A
  • HDACA
  • HD4
  • HA6116
  • HDAC-4
• GenBank acession
  • AB006626
• Locus
  2q37.3
• Discovery year
  2000-11-28
• Entrez gene record
  9759
• Pubmed identfication
  • 10206986
  • 10220385
  • 20691407
• RefSeq identity
  • NM_006037
• Classification
  • Histone deacetylases, class IIA
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133344

Gene info

• Identity
  HGNC:5164
• Gene
  HPSE
• Long gene name
  heparanase
• Synonyms
  • HPA
  • HSE1
  • HPSE1
• GenBank acession
  • AF144325
• Locus
  4q21.23
• Discovery year
  1999-09-28
• Entrez gene record
  10855
• Pubmed identfication
  • 10395325
  • 10395326
• RefSeq identity
  • NM_006665
• Classification
  • Heparanases
• VEGA ID
  OTTHUMG00000130425

Gene info

• Identity
  HGNC:14065
• Gene
  HDAC9
• Long gene name
  histone deacetylase 9
• Synonyms
  • KIAA0744
  • HDAC
  • MITR
  • HD7
  • HDAC7B
• GenBank acession
  • AF124924
• Locus
  7p21.1
• Discovery year
  2002-09-06
• Entrez gene record
  9734
• Pubmed identfication
  • 10523670
  • 10487760
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000152487

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