HPA, HDAC inhibitor
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Catalog numberSIH-356-50MG
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Price:
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Size50 mg
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Stock availabilitIn StockIn Stock
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CAS number96017-59-3
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DescriptionHDAC inhibitor
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Molecular weight182,3 g/mol
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Primary research fieldsCell Signaling, Epigenetics, Cancer
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Other name2-(2-propynyl)octanoic acid, HPA
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC11H11O2
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OriginSynthetic
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Purity pourcentage>97% (TLC), NMR conforms
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Soluble inSoluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
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Physical appearanceColorless Oil
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number175664
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Scientific contextHistone deacetylase (HDAC) inhibitor, IC50=13 µM Histone deacetylase (HDAC) inhibitor, IC50=13 µM
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Bibliography1. Eikel D., et al. (2006) Chem. Res. Toxicol. 19: 272. 2. Leng Y., et al. (2010) Neurosci. Lett. 476: 127.
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Release date1-Aug-2012
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Hexyl-4-pentynoic Acid (SIH-356), a HDAC inhibitor. CAS #: 96017-59-3. Molecular Formula: C11H11O2. Molecular Weight: 182.3 g/mol. Chemical structure of Hexyl-4-pentynoic Acid, a HDAC inhibitor (SIH-356). CAS # 96017-59-3. Molecular Formula: C11H11O2.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.05
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolHDAC4, HPSE, HDAC9
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Short nameHPA, HDAC inhibitor
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Alternative nameHPA, HDAC suppressor
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Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameheparanase
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Heparanases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID