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Stock availabilitIn Stock
In Stock
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CAS number
1716-12-7
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Description
HDAC inhibitor
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Molecular weight
186,18 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors
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Other name
Sodium 4-phenylbutanoate, 4-PB
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C10H11NaO2
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 1100 mM in water and 100 mM in DMSO
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Physical appearance
White solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
5258
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Scientific context
Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
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Bibliography
1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54. 2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Phenylbutyrate Na (SIH-255), a Histone deacetylase inhibitor. CAS #: 1716-12-7. Molecular Formula: C10H11NaO2. Molecular Weight: 186.18 g/mol. Chemical structure of Phenylbutyrate Na, a Histone deacetylase inhibitor (SIH-255). CAS # 1716-12-7. Molecular Formula: C10H11NaO2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.5
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
