Human CellExp™ FGF-2/FGF-basic, Human Recombinant

  • Catalog number
    6448-10
  • Price
    Please ask
  • Size
    10 ug
  • Synonyms
    Human Cellexp Human Recombinant FGF-basic
  • Alternative_names
    Prostatropin, HBGH-2, HBGF-2, FGF-2, FGF-b.
  • Description
    A growth factor involved in angiogenesis, wound healing and embryonic development
  • Recombinant
    Yes
  • Source
    Human cell expressed
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Endotoxin Level
    < 1.0 EU per 1 ug of protein
  • Biological activity
    ED₅₀ is typically 0.1 to 0.5 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of the 3T3 cell line.
  • Results
    0.1 to 0.5 ng/ml
  • Molecular Weight
    17 kDa, monomer, non-glycosylated
  • Storage Temp
    -20°C
  • Shipping
    gel pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from a PBS solution.
  • Reconstitution Instructions
    Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
  • Background Information
    FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Additional description
    Basic proteins pH>7 are often produced recombinant and shouldn’t be precipitated by formic acid buffer.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    FGF18, FGF17, NUDT6, FGF2, FGF4, FGF1, FGF13, MIR1289-2, MIR521-2, MIR509-2
  • Short name
    CellExp™ FGF-2/FGF- , Recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ FGF-2/FGF-basic, H. sapiens Rec.
  • Alternative technique
    rec
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    fibroblast growth factor 2
  • Synonyms gene
  • Synonyms gene name
    • fibroblast growth factor 2 (basic)
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Fibroblast growth factor family
    • Receptor ligands
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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